The Influence of Available Fluid on the Production of Experimental Hemoglobinuric Nephrosis in Rabbits

The importance of previous dehydration on the production of hemoglobinuric nephrosis is substantiated. Hemoglobinuric nephrosis regularly occurred in rabbits 3 to 16 days following the injections of hemoglobin. Five of 15 animals died of fatal hemoglobinuric nephrosis; the combined kidney weight in these exceeded the weight of the kidneys of control rabbits and of those which survived. Additional observations, not previously made, are focal necrosis of the liver and pulmonary edema in some of the rabbits which died. A relationship was evident between the quantity of available fluid and the severity of the hemoglobinuric nephrosis which developed after injections of hemoglobin.